Vaccinating Against Plaques
Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals...
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Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals...
Clinical testing of ACC-001, Elan’s second-generation Aβ vaccine, is back on track...
Are you sometimes tempted to view APP and presenilin merely as raw material and machine for Aβ production, respectively? If so, think again, because that narrow spotlight is opening up to a broader understanding of how these two proteins function and might contribute to Alzheimer’s...
The regulation of neuronal plasticity and regeneration in the CNS is an aspect of Alzheimer’s disease that often has to compete with the big stars, such as amyloid or presenilin, for attention...
Researchers have suspected retroviruses to play a role in amyotrophic lateral sclerosis (ALS) since the 1960s, when poliomyelitis was proposed to contribute to progression of the disease...
What if all it took was a little sugar—not to make some other medicine go down, but as a therapy in itself for Huntington's disease? This is the promise of an article published...
In the genetics of late-onset Alzheimer disease, ApoE is the big fish...
The Wellcome Trust announced this week that it will fund what it describes as the largest ever Alzheimer’s gene study...
Read about this update of Martin Schwab's efforts to rekindle spinal cord regeneration with antibodies against the growth inhibitor nogo.
Among the strategies currently being pursued for treatment of Alzheimer disease (AD), inhibiting...
Perhaps some good can come from the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT)...
A recent population-based study supports the idea that in the oldest old, the relationship between plaques and tangles, and dementia, may be more legend than substance...
Back-to-back papers in today’s Science shed new light on the role that insulin and heat shock proteins may play in the aging process...
Neuronal progenitors are faced with many forks on the road to becoming one of more than 1,000 different neurons found in the human central nervous system...
Two new papers reveal how environmental influences can directly affect the activity of the APP-processing enzymes β-secretase (BACE1) and γ-secretase...
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